Name: AICAR
SKU: AIC-00
Availability: BackOrder

AICAR

EhBuddy Research-Grade AICAR — Available in 50mg Vial, 100mg Vial

AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide) is a potent AMPK activator and AMP mimetic that triggers cellular energy-sensing pathways. Research demonstrates AICAR mimics the effects of endurance exercise at the molecular level — improving glucose uptake, fat oxidation, mitochondrial biogenesis, and endurance capacity in sedentary research models without physical exertion.

Reconstitution: Bacteriostatic Water (BAC Water) or Sterile Water required.

FOR RESEARCH USE ONLY (RUO). Not approved for human or veterinary use. Intended for in vitro and laboratory research only.

Free shipping on Canadian orders over $350

⏱ On Backorder — Estimated dispatch within 8 business days for most backorders. Shipping notification sent by email once dispatched.

Description

AICAR — AMPK Activator | Exercise Mimicry & Metabolic Research

AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide) is a cell-permeable nucleoside that is phosphorylated intracellularly to AICA-ribotide (ZMP) — an AMP analogue that directly activates AMPK (AMP-activated protein kinase). AMPK is the master metabolic switch that activates during exercise and energy deficit, triggering glucose uptake, fatty acid oxidation, and mitochondrial biogenesis. AICAR is the most widely used AMPK activator in research, enabling exercise-pathway research in non-exercising models.

Available Formats

50mg Vial
100mg Vial

Reconstitution: Reconstitute with Bacteriostatic Water (BAC Water) for multi-use stability, or Sterile Water for single-use protocols. Store lyophilized vials at 2–8°C.

Key Research Areas

⚡ AMPK Activation & Exercise Mimicry

Landmark Salk Institute research demonstrated AICAR-treated sedentary mice ran 44% farther than controls on a treadmill — without any exercise training. AICAR activates the same AMPK pathways engaged during endurance exercise, making it the gold standard for studying exercise-metabolism crosstalk.

🩸 Glucose Uptake & Insulin Sensitivity

AMPK activation stimulates GLUT4 translocation to muscle cell membranes, increasing glucose uptake independently of insulin. Research models show significant insulin sensitization, blood glucose reduction, and protection against insulin resistance development.

🔥 Fat Oxidation & Mitochondrial Biogenesis

AICAR activates PGC-1α and drives mitochondrial biogenesis — increasing muscle oxidative capacity, fat oxidation, and metabolic flexibility. Research models show increased mitochondrial number and function, consistent with endurance training adaptations.

❤️ Cardioprotection Research

AMPK activation has documented cardioprotective effects in ischemia-reperfusion models. AICAR research has demonstrated reduced infarct size, improved cardiac function post-ischemia, and protection against cardiomyocyte apoptosis.

Why Choose EhBuddy?

✅ Verified Purity — Third-party tested for identity and potency
✅ Fast Canadian Shipping — Discreet packaging, shipped from Canada
✅ Research-Grade Quality — Strict QC manufacturing standards

FOR RESEARCH USE ONLY (RUO). Not approved for human or veterinary use. Intended for in vitro and laboratory research only.

Additional information

Weight	0.05 lbs
Measurement	50mg Vial , 100mg Vial

🔬 Research Notes

⚗️ For Research Use Only. All products are intended strictly for laboratory and scientific research. Not for human or veterinary consumption.

This compound is sold strictly for laboratory and scientific research. Please consult peer-reviewed literature for research protocols and pharmacological data.

COA

View the Certificate of Analysis (HPLC) for this product. All testing is now performed by PeakPurePeps — a local, Canadian-owned lab. If a COA for your selected batch isn’t posted yet, testing is in progress or we’re awaiting our next restock.

View this product’s COA ›

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Shipping & Delivery

Shipping & Delivery Information

Free Shipping on all orders over $350 CAD. Orders under $350 CAD are subject to a flat shipping fee.

Carriers: We ship via Canada Post Xpresspost and other couriers to ensure reliable delivery across Canada.

Estimated Delivery Times:

Ontario & Quebec: 1–3 business days
Western Canada (BC, AB, SK, MB): 2–5 business days
Atlantic Canada: 3–5 business days
Northern Territories: 5–10 business days

Packaging: All orders ship in discreet, unmarked packaging. No product names or company branding appear on the exterior.

Tracking: A tracking number will be emailed once your order ships. Most orders ship within 1 business day of payment confirmation.

Temperature-Sensitive Items: Lyophilized (freeze-dried) peptides are stable at room temperature for shipping. Store at 2–8°C upon receipt for long-term stability.

Questions? Contact us at Contact@EhBuddyPeptides.io

Disclaimer

You must be 18 or 19 years of age depending on the age of majority in your province and a licensed research professional.

All products — including research peptides and research compounds — are sold strictly for laboratory and scientific research purposes only. Not for human or veterinary consumption. No dosing instructions are provided.

We adhere to all provincial and federal laws in Canada governing Research Only Chemical sales.

By clicking "I Agree" you confirm you have read and accepted the Terms and Conditions above.

AICAR