5-Amino-1MQ — NNMT Inhibitor | Fat Loss & Metabolic Research
5-Amino-1-methylquinolinium (5-Amino-1MQ) is a cell-permeable small molecule that selectively inhibits NNMT (Nicotinamide N-methyltransferase) — an enzyme highly expressed in adipose tissue that consumes SAM (S-adenosylmethionine) and reduces NAD+ precursor availability while promoting fat cell expansion. By inhibiting NNMT, 5-Amino-1MQ redirects cellular metabolism toward fat oxidation and NAD+ synthesis — producing significant metabolic effects in research models without dietary intervention.
Available Formats
- 5mg
- 10mg
- 50mg
Reconstitution: Reconstitute with Bacteriostatic Water (BAC Water) for multi-use stability, or Sterile Water for single-use protocols. Store lyophilized vials at 2–8°C.
Key Research Areas
🔥 Fat Cell Reduction Without Caloric Restriction
Research in diet-induced obesity mouse models demonstrates 5-Amino-1MQ treatment results in significant fat mass reduction and smaller fat cell size without changes in food intake. NNMT inhibition essentially programs adipocytes to burn rather than store fat.
⚡ NAD+ Pathway Upregulation
By blocking NNMT’s consumption of SAM (the methyl donor that competes with NAD+ precursors), 5-Amino-1MQ increases intracellular NAD+ levels and SIRT1 activation — converging with NAD+ supplementation research pathways but via an entirely different mechanism.
🧬 Epigenetic Metabolic Reprogramming
NNMT influences histone methylation patterns that control metabolic gene expression in fat tissue. Research shows 5-Amino-1MQ shifts adipose tissue gene expression toward a thermogenic brown/beige fat phenotype — an active area of obesity research.
💪 Lean Mass Preservation
Unlike caloric restriction, 5-Amino-1MQ research models show fat-specific loss with preservation of lean muscle mass — a highly desirable body composition profile for obesity and metabolic disease research.
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- ✅ Verified Purity — Third-party tested for identity and potency
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FOR RESEARCH USE ONLY (RUO). Not approved for human or veterinary use. Intended for in vitro and laboratory research only.
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