MGF (Mechano Growth Factor)

MGF (Mechano Growth Factor) — Native IGF-1 Splice Variant | Muscle Research

Mechano Growth Factor (MGF) is the native, non-PEGylated form of the locally expressed IGF-1 splice variant produced in mechanically stressed muscle tissue. Its unique C-terminal E-domain activates satellite cells through a receptor mechanism distinct from IGF-1Ea — making MGF a critical research tool for understanding muscle repair signalling in response to mechanical load, injury, and resistance exercise stimulation.

Reconstitution: Reconstitute with Bacteriostatic Water (BAC Water) for multi-use stability, or Sterile Water for single-use protocols. Store lyophilized vials at 2–8°C.

Key Research Areas

💪 Local Satellite Cell Activation Research

MGF acts locally and rapidly — triggering satellite cell activation within hours of muscle damage or mechanical loading. Research uses MGF’s short half-life as an advantage for studying the acute phase of muscle repair signalling before the chronic IGF-1Ea phase takes over.

🔬 Mechanobiology Research

MGF is the primary molecular mediator of the muscle’s response to mechanical load — the fundamental signal linking exercise to muscle growth. Research into mechano-transduction pathways, exercise physiology, and load-induced hypertrophy routinely uses MGF as the key response marker and research tool.

🧬 Comparison vs. PEG-MGF & IGF-1

Research comparing native MGF, PEG-MGF, and IGF-1Ea enables dissection of immediate vs. sustained satellite cell signalling and local vs. systemic IGF-1 isoform biology — fundamental questions in growth factor research.

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FOR RESEARCH USE ONLY (RUO). Not approved for human or veterinary use. Intended for in vitro and laboratory research only.