Follistatin — Natural Myostatin Antagonist | Muscle & Research
Follistatin (FST) is an endogenous secreted glycoprotein that binds and neutralizes members of the TGF-β superfamily — most critically Myostatin (GDF-8) and Activin A — the primary biological brakes on skeletal muscle growth. By antagonizing these inhibitory signals, Follistatin removes the ceiling on muscle fiber size and number. Research in transgenic animal models with Follistatin overexpression produces muscle mass 2–4x normal — making it one of the most powerful muscle-modulating compounds in biology.
Available Formats
- 1 mg
Reconstitution: Reconstitute with Bacteriostatic Water (BAC Water) for multi-use stability, or Sterile Water for single-use protocols. Store lyophilized vials at 2–8°C.
Key Research Areas
💪 Myostatin Antagonism & Muscle Mass
Follistatin’s primary research application is Myostatin neutralization. Studies in mice with Follistatin gene overexpression show muscle mass increases of 194–327% — among the most dramatic muscle growth outcomes in mammalian research. Applications include muscle wasting, sarcopenia, Duchenne muscular dystrophy, and cachexia models.
⚡ Activin Antagonism & Performance
Follistatin neutralizes Activin A — which independently limits muscle growth via SMAD2/3 signalling. This dual antagonism (Myostatin + Activin) provides broader anabolic signalling relief than Myostatin-specific compounds alone.
🌸 Reproductive & Fertility Research
Follistatin regulates FSH (follicle-stimulating hormone) secretion by antagonizing Activin in the pituitary. Research explores FST’s role in ovarian follicle development, female fertility, PCOS, and menopause models.
💇 Hair Follicle Research
Follistatin promotes hair follicle cycling and may extend the anagen (growth) phase. Research has documented increased hair growth in FST-overexpressing models — an area of dermatological research interest.
Why Choose EhBuddy?
- ✅ Verified Purity — Third-party tested for identity and potency
- ✅ Fast Canadian Shipping — Discreet packaging, shipped from Canada
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FOR RESEARCH USE ONLY (RUO). Not approved for human or veterinary use. Intended for in vitro and laboratory research only.
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