ACE-031 (ActRIIB-Fc) — Multi-Ligand Muscle Inhibitor Blocker | Research
ACE-031 is a recombinant fusion protein consisting of the extracellular domain of Activin Receptor Type IIB (ActRIIB) fused to human IgG1-Fc. This soluble decoy receptor competitively binds and sequesters multiple TGF-β family members that limit muscle growth — including Myostatin, Activin A, Activin B, GDF-11, and BMP9/10 — producing a broader and more potent muscle-promoting effect than Myostatin-specific blockers alone. Acceleron Pharma’s Phase 2 research in healthy men demonstrated 3% lean mass increase and 2% fat loss in just 4 weeks.
Reconstitution: Reconstitute with Bacteriostatic Water (BAC Water) for multi-use stability, or Sterile Water for single-use protocols. Store lyophilized vials at 2–8°C.
Key Research Areas
💪 Multi-Pathway Muscle Promoter
By trapping Myostatin AND Activin simultaneously, ACE-031 removes more anabolic brakes than Myostatin-only antagonists. Phase 2 data in healthy adults demonstrated significant lean mass gains within 4 weeks — one of the fastest and most dramatic muscle-promoting effects seen in any pharmacological research.
🏥 Muscle Wasting Disease Research
ACE-031 is under clinical investigation for Duchenne muscular dystrophy, with research models in DMD mice showing substantial muscle mass restoration and improved muscle function. Applications extend to ALS, cancer cachexia, and age-related sarcopenia research.
🔥 Fat Mass Reduction
Phase 2 data showed simultaneous fat loss alongside lean mass gains — likely driven by Activin receptor pathway effects on adipogenesis. This dual body composition effect is a research area of particular interest.
🦴 Bone Density Research
ActRIIB ligands include BMP9/10 which influence bone formation. ACE-031 research has shown increased bone mineral density markers, suggesting applications in osteoporosis and bone wasting research.
Why Choose EhBuddy?
- ✅ Verified Purity — Third-party tested for identity and potency
- ✅ Fast Canadian Shipping — Discreet packaging, shipped from Canada
- ✅ Research-Grade Quality — Strict QC manufacturing standards
FOR RESEARCH USE ONLY (RUO). Not approved for human or veterinary use. Intended for in vitro and laboratory research only.
Reviews
There are no reviews yet.