KPV (Lysine-Proline-Valine) — α-MSH C-Terminal Tripeptide | Anti-Inflammatory Research
KPV is the C-terminal tripeptide of alpha-Melanocyte-Stimulating Hormone (α-MSH, sequence: …Lys-Pro-Val-NH₂). Research has established that this tripeptide carries a significant portion of α-MSH’s anti-inflammatory biological activity in a minimal, highly stable format. Unlike full α-MSH (13 amino acids), KPV’s small size enables cell penetration and potential oral bioavailability in some research formulations — positioning it as a next-generation anti-inflammatory research compound.
Available Formats
- 5mg | 10mg
- 5mg
- 10mg
Reconstitution: Reconstitute with Bacteriostatic Water (BAC Water) for multi-use stability, or Sterile Water for single-use protocols. Store lyophilized vials at 2–8°C.
Key Research Areas
🔬 NF-κB Inhibition & Anti-Inflammatory Mechanism
KPV directly inhibits NF-κB nuclear translocation in immune and epithelial cells, blocking the master inflammatory transcription factor. Research shows reductions in TNF-α, IL-6, IL-1β, and other pro-inflammatory cytokines across multiple research models.
🫀 IBD & Gut Inflammation Research
KPV has shown remarkable efficacy in colitis models — significantly reducing inflammatory markers, preserving intestinal barrier function, and accelerating mucosal healing. Research has explored both systemic and oral delivery for GI-targeted research.
🩹 Wound Healing
Consistent with its parent molecule α-MSH, KPV accelerates wound contraction, reduces wound inflammation, and promotes epithelialization. Research models show faster wound closure and reduced inflammatory infiltrate vs. controls.
🛡️ MC1R Research
KPV retains partial MC1R agonist activity from its parent α-MSH, enabling research into melanocortin receptor-mediated anti-inflammatory pathways in a minimal peptide scaffold.
Why Choose EhBuddy?
- ✅ Verified Purity — Third-party tested
- ✅ Fast Canadian Shipping — Discreet packaging, shipped from Canada
- ✅ Research-Grade Quality — Strict QC standards
FOR RESEARCH USE ONLY (RUO). Not approved for human or veterinary use. Intended for in vitro and laboratory research only.
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