Dermorphin — Ultra-Potent Mu-Opioid Peptide | Opioid Research Reference
Dermorphin (H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH₂) is a heptapeptide first isolated from the skin secretions of Phyllomedusa sauvagei — a South American frog. Its discovery was groundbreaking: Dermorphin contains a D-alanine residue at position 2, making it the first D-amino acid peptide identified in a vertebrate species. This D-amino acid confers exceptional resistance to enzymatic degradation and dramatically enhances mu-opioid receptor binding — producing approximately 1,000× the analgesic potency of morphine in pre-clinical research models.
Reconstitution: Reconstitute with Bacteriostatic Water (BAC Water) for multi-use stability, or Sterile Water for single-use protocols. Store lyophilized vials at 2–8°C.
Key Research Areas
🔬 Mu-Opioid Receptor Pharmacology
Dermorphin is among the most selective MOR agonists known — with high MOR affinity and minimal activity at delta or kappa opioid receptors. It serves as a gold standard reference compound for studying MOR binding, activation, G-protein coupling, and receptor internalization dynamics.
😌 Pain Research Reference
Dermorphin’s ~1,000x potency vs. morphine makes it invaluable for ultra-low-dose pain research, pain pathway mapping, and studies exploring the quantitative relationship between receptor occupancy and analgesic response in pre-clinical models.
🧬 D-Amino Acid Peptide Biology
As the prototype vertebrate D-amino acid peptide, Dermorphin research has contributed fundamental knowledge about how D-amino acid incorporation alters peptide conformation, receptor selectivity, metabolic stability, and bioavailability — with implications for peptide drug design research.
🧠 Endogenous Opioid System Research
Dermorphin’s extreme potency and selectivity make it a tool for dissecting central and peripheral opioid circuits — mapping MOR distribution, studying opioid-mediated analgesia, tolerance, and dependence mechanisms in research models.
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FOR RESEARCH USE ONLY (RUO). Not approved for human or veterinary use. Intended for in vitro and laboratory research only.
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