Alprostadil

Alprostadil (PGE1) — Prostaglandin Vasodilator | Vascular & Erectile Function Research

Alprostadil is the synthetic form of Prostaglandin E1 (PGE1) — a naturally occurring eicosanoid with potent vasodilatory, antiplatelet, and cytoprotective properties. Alprostadil binds prostaglandin EP receptors on smooth muscle cells, activating adenylyl cyclase and relaxing vascular smooth muscle via cAMP-mediated signalling. FDA-approved as Caverject® and MUSE® for erectile dysfunction and as Prostin VR® for neonatal ductus arteriosus patency, Alprostadil provides an exceptional evidence base for vascular and reproductive research.

Storage: Alprostadil in solution is stable when refrigerated at 2–8°C. Follow reconstitution guidance per your research protocol.

Key Research Areas

🔬 Erectile Function & Penile Vascular Research

Alprostadil produces tumescence via direct corpus cavernosum smooth muscle relaxation and increased arterial inflow. As FDA-approved Caverject, it provides regulatory-quality clinical evidence for penile vascular biology research and is the gold standard for comparing novel erectile function compounds.

❤️ Peripheral Vascular Disease Research

PGE1’s vasodilatory, antiplatelet, and anti-inflammatory effects make Alprostadil a key compound in peripheral arterial disease, critical limb ischemia, and Raynaud’s syndrome research — with clinical evidence supporting its role in vascular protection.

👶 Neonatal Cardiology Research

Alprostadil maintains ductus arteriosus patency in neonates with congenital heart disease by preventing prostaglandin-mediated ductus closure. This is a life-saving emergency medicine application with extensive evidence, used as a bridge to surgical correction in research models of ductal-dependent congenital heart defects.

🛡️ Cytoprotective & Renal Research

PGE1 shows direct cytoprotective effects on renal tubular cells and the gastric mucosa. Research explores Alprostadil’s role in contrast nephropathy prevention, renal ischemia protection, and gastroprotection models.

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FOR RESEARCH USE ONLY (RUO). Not approved for human or veterinary use. Intended for in vitro and laboratory research only.