Sermorelin Acetate — GHRH(1-29) | Physiological GH Research
Sermorelin acetate is the synthetic form of GHRH(1-29)NH₂ — the first 29 amino acids of human Growth Hormone-Releasing Hormone. As the biologically active fragment of endogenous GHRH, Sermorelin was FDA-approved as Geref® for GH deficiency diagnosis and pediatric GH deficiency treatment before its withdrawal for commercial reasons. This regulatory approval history provides Sermorelin with some of the most comprehensive clinical evidence of any GHRH-class research compound.
Available Formats
- 5mg
- 10mg
Reconstitution: Reconstitute with Bacteriostatic Water (BAC Water) for multi-use stability, or Sterile Water for single-use protocols. Store lyophilized vials at 2–8°C.
Key Research Areas
⚡ Physiological GHRH Research
Sermorelin’s sequence identity with endogenous GHRH(1-29) makes it the gold standard for studying natural GH pulse dynamics. Research demonstrates it stimulates pulsatile GH release while preserving hypothalamic-pituitary feedback — unlike exogenous GH, which suppresses natural production.
💪 GH Deficiency Research
FDA-approved clinical data confirms Sermorelin’s ability to restore GH/IGF-1 levels in GH-deficient pediatric and adult populations. This evidence base makes Sermorelin a reference compound in adult-onset GH deficiency and anti-aging GH research.
🧬 Somatotroph Function Research
Unlike synthetic GHRH analogues with modified half-lives, Sermorelin’s native-like pharmacokinetics allow research into authentic somatotroph pulsatile dynamics, desensitization mechanisms, and GH pulse physiology.
💤 Sleep & Recovery
GH secretion peaks during slow-wave sleep. Sermorelin research has documented improvements in sleep architecture quality and night-time GH pulse amplification — linking GH axis research to sleep medicine research.
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FOR RESEARCH USE ONLY (RUO). Not approved for human or veterinary use. Intended for in vitro and laboratory research only.
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