Name: FOXO4
SKU: FOX-00
Price: 494.00 CAD
Availability: BackOrder

FOXO4

$494.00

EhBuddy Research-Grade FOXO4-DRI — 10mg

FOXO4-DRI is a D-amino acid retro-inverso peptide designed to interfere with the FOXO4-p53 interaction that keeps senescent cells alive. Research in aged mouse models demonstrates dramatic elimination of senescent cells (senolytics), restoration of lost fur, improved physical fitness, and organ function recovery — making FOXO4-DRI one of the most compelling senolytic compounds in longevity research.

Reconstitution: Bacteriostatic Water (BAC Water) required.

FOR RESEARCH USE ONLY (RUO). Not approved for human or veterinary use. Intended for in vitro and laboratory research only.

Free shipping on Canadian orders over $350

⏱ On Backorder — Estimated dispatch within 8 business days for most backorders. Shipping notification sent by email once dispatched.

Description

FOXO4-DRI — Senolytic Peptide | Cellular Senescence Research

FOXO4-DRI is a D-amino acid retro-inverso (DRI) peptide antagonist of the FOXO4-p53 protein interaction. Senescent cells — “zombie cells” that no longer divide but resist apoptosis — accumulate with aging and secrete SASP (Senescence-Associated Secretory Phenotype) factors that drive chronic inflammation and tissue dysfunction. FOXO4-DRI specifically disrupts the FOXO4-p53 interaction that maintains senescent cell survival, triggering apoptosis selectively in senescent but not healthy cells. The original Nature Medicine paper demonstrated remarkable rejuvenation effects in aged and chemotherapy-treated mice.

Available Formats

10mg

Reconstitution: Reconstitute with Bacteriostatic Water (BAC Water) for multi-use stability, or Sterile Water for single-use protocols. Store lyophilized vials at 2–8°C.

Key Research Areas

🧬 Targeted Senescent Cell Clearance

FOXO4-DRI selectively induces apoptosis in FOXO4-high senescent cells while leaving proliferating cells unharmed. Research confirms specificity via the selective upregulation of p21 and p53 in senescent but not normal cells — establishing FOXO4-DRI as one of the most selective senolytic tools available.

⚡ Rejuvenation Research (Aged Mouse Models)

Original Nature Medicine (2017) research demonstrated that 3 intraperitoneal injections per week for 3 weeks in aged mice produced: restoration of lost fur, improved physical fitness, reduced frailty, and improved renal function. This represents among the most compelling aging reversal data published for any peptide compound.

🏥 Chemotherapy-Induced Senescence Research

Chemotherapy induces widespread senescence contributing to off-target toxicity. FOXO4-DRI research in chemotherapy-treated mice showed restoration of white blood cell counts, hair retention, and physical function — relevant to reducing treatment-related aging in cancer research models.

🔬 SASP & Inflammaging Research

Clearing senescent cells reduces SASP factor secretion (IL-6, IL-1β, TNF-α), normalizing the chronic low-grade inflammatory environment (“inflammaging”) that drives age-related disease. FOXO4-DRI enables mechanistic inflammaging research.

Why Choose EhBuddy?

✅ Verified Purity — Third-party tested
✅ Fast Canadian Shipping — Discreet packaging, shipped from Canada
✅ Research-Grade Quality — Strict QC standards

FOR RESEARCH USE ONLY (RUO). Not approved for human or veterinary use. Intended for in vitro and laboratory research only.

Additional information

Weight	0.1 lbs
Measurement	10mg

🔬 Research Notes

⚗️ For Research Use Only. All products are intended strictly for laboratory and scientific research. Not for human or veterinary consumption.

Longevity peptides including Epitalon, Thymalin, and pineal-derived compounds are studied for telomere length modulation, melatonin regulation, and thymic function restoration. NAD+ precursors and mitochondria-targeted compounds (SS-31, MOTS-C) are studied for mitochondrial biogenesis and oxidative stress reduction.

COA

View the Certificate of Analysis (HPLC) for this product. All testing is now performed by PeakPurePeps — a local, Canadian-owned lab. If a COA for your selected batch isn’t posted yet, testing is in progress or we’re awaiting our next restock.

View this product’s COA ›

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Shipping & Delivery

Shipping & Delivery Information

Free Shipping on all orders over $350 CAD. Orders under $350 CAD are subject to a flat shipping fee.

Carriers: We ship via Canada Post Xpresspost and other couriers to ensure reliable delivery across Canada.

Estimated Delivery Times:

Ontario & Quebec: 1–3 business days
Western Canada (BC, AB, SK, MB): 2–5 business days
Atlantic Canada: 3–5 business days
Northern Territories: 5–10 business days

Packaging: All orders ship in discreet, unmarked packaging. No product names or company branding appear on the exterior.

Tracking: A tracking number will be emailed once your order ships. Most orders ship within 1 business day of payment confirmation.

Temperature-Sensitive Items: Lyophilized (freeze-dried) peptides are stable at room temperature for shipping. Store at 2–8°C upon receipt for long-term stability.

Questions? Contact us at Contact@EhBuddyPeptides.io

Disclaimer

You must be 18 or 19 years of age depending on the age of majority in your province and a licensed research professional.

All products — including research peptides and research compounds — are sold strictly for laboratory and scientific research purposes only. Not for human or veterinary consumption. No dosing instructions are provided.

We adhere to all provincial and federal laws in Canada governing Research Only Chemical sales.

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FOXO4