IGF-1 LR3 — Long-Acting Insulin-like Growth Factor | Muscle & Anabolic Research
IGF-1 LR3 (Long R3 IGF-1) is a recombinant analogue of IGF-1 with three structural modifications: an N-terminal arginine extension, a glutamic acid substitution at position 3, and an R3→L3 substitution — collectively reducing IGF-binding protein (IGFBP) affinity by >90%. This dramatically extends plasma half-life from ~12 minutes (native IGF-1) to 70–120 hours, enabling sustained anabolic receptor activation for research purposes.
Available Formats
- 0.1 mg
- 1mg
Reconstitution: Add 0.6% Acetic Acid first to dissolve the powder, then dilute with BAC Water or Sterile Water. Store at 2–8°C.
Key Research Areas
💪 Muscle Hyperplasia & Satellite Cell Research
Unlike GH or standard IGF-1, IGF-1 LR3’s extended half-life provides sustained activation of IGF-1R on muscle cells. Research demonstrates not just hypertrophy but true muscle fiber hyperplasia (new fiber formation) via satellite cell activation — a biologically distinct and more permanent form of muscle growth studied in sarcopenia and muscle wasting models.
⚡ Anabolic Signalling Cascade
IGF-1 LR3 activates PI3K/Akt/mTOR and MAPK/ERK pathways — the master anabolic cascades governing protein synthesis, cell growth, and anti-apoptosis. Research in muscle wasting, cachexia, and frailty models shows potent lean mass restoration.
🔥 Fat Oxidation & Metabolic Research
IGF-1R activation promotes fatty acid uptake and oxidation in muscle tissue while reducing adipogenesis. Research models show preferential fat loss alongside lean mass gain — a highly sought metabolic profile in body composition research.
🧠 Neuroprotection & Neurogenesis
IGF-1 is a critical neurotrophic factor. Research demonstrates IGF-1 LR3’s ability to cross the blood-brain barrier, promote hippocampal neurogenesis, protect against neurotoxic insults, and improve cognitive function in aging and neurological research models.
Why Choose EhBuddy?
- ✅ Verified Purity — Third-party tested for identity and potency
- ✅ Fast Canadian Shipping — Discreet packaging, shipped from Canada
- ✅ Research-Grade Quality — Strict QC manufacturing standards
FOR RESEARCH USE ONLY (RUO). Not approved for human or veterinary use. Intended for in vitro and laboratory research only.
Sophie W. –
IGF-1 LR3 from EhBuddy is quality I can trust. Been ordering for 4 months and consistency is perfect. Quick shipping, professional packaging. Highly recommend for Canadian researchers.