Semax — ACTH(4-10) Analogue | Neuroprotection & Cognitive Research
Semax (MEHFPGP) is a synthetic heptapeptide analogue of ACTH(4-10) developed at the Institute of Molecular Genetics in Moscow. It lacks the hormonal activity of full ACTH but retains and amplifies the neurotrophic and neuroprotective properties of the ACTH melanocortin fragment. Semax is licensed as a pharmaceutical drug in Russia for neurological and cardiovascular conditions, giving it a unique evidence base among research peptides.
Available Formats
- 5mg
- 10mg
Reconstitution: Reconstitute with Bacteriostatic Water (BAC Water) for multi-use stability, or Sterile Water for single-use protocols. Store lyophilized vials at 2–8°C.
Key Research Areas
🧠 BDNF & NGF Upregulation
Semax significantly increases BDNF (Brain-Derived Neurotrophic Factor) and NGF (Nerve Growth Factor) expression in the hippocampus and frontal cortex. Research models show enhanced neuroplasticity, improved learning and memory consolidation, and dendritic density increases — the core mechanisms driving its cognitive research interest.
⚡ Cognitive Enhancement Research
Research in animal models and clinical studies demonstrates improved attention, working memory, and executive function. The melanocortin-dopamine interaction may underlie enhanced focus and cognitive processing speed documented in Semax studies.
🩺 Stroke & Ischemia Neuroprotection
Russian clinical research documents Semax’s neuroprotective effects in acute ischemic stroke models — reducing infarct size, promoting neurological recovery, and accelerating rehabilitation outcomes. It is an approved pharmaceutical in Russia for this indication.
🔬 Anti-Anxiety & Stress Response
ACTH melanocortin fragments modulate the HPA axis. Semax research shows anxiolytic properties and normalization of stress-induced cortisol dysregulation in animal models — explored for anxiety and PTSD research contexts.
🧬 Neuroinflammation Research
Studies show Semax modulates neuroinflammatory cytokines, potentially reducing astrocyte activation and microglial-mediated damage in neurodegenerative research models.
Why Choose EhBuddy?
- ✅ Verified Purity — Third-party tested for identity and potency
- ✅ Fast Canadian Shipping — Discreet packaging, shipped from Canada
- ✅ Research-Grade Quality — Strict manufacturing quality standards
- ✅ Pharmaceutical-Grade Standard — Matching the purity requirements of licensed European markets
FOR RESEARCH USE ONLY (RUO). Not approved for human or veterinary use. Intended for in vitro and laboratory research only. EhBuddy Peptides assumes no liability for misuse.














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