LL-37 (Cathelicidin) — Human Host-Defence Peptide | Innate Immunity Research
LL-37 is the only cathelicidin expressed in humans — a 37-amino-acid amphipathic alpha-helical peptide produced by neutrophils, monocytes, NK cells, and epithelial cells. As a critical component of the innate immune system, LL-37 bridges antimicrobial defence, immune signalling, and tissue repair. It disrupts bacterial membranes via electrostatic interaction, modulates TLR signalling, promotes wound healing, and has demonstrated anti-tumor activity — making it one of the most multifunctional host-defence peptides in research.
Reconstitution: Reconstitute with Bacteriostatic Water (BAC Water) for multi-use stability, or Sterile Water for single-use protocols. Store lyophilized vials at 2–8°C.
Key Research Areas
🦠 Broad-Spectrum Antimicrobial Research
LL-37 disrupts bacterial, fungal, and viral membranes through amphipathic insertion — a mechanism that is difficult for pathogens to develop resistance against. Research documents activity against Gram-positive and Gram-negative bacteria, including antibiotic-resistant strains like MRSA and P. aeruginosa — positioning LL-37 as a lead compound in anti-infective peptide research.
🛡️ Immunomodulation Research
LL-37 acts as a danger signal — activating dendritic cells, mast cells, and macrophages while modulating TLR4 signalling. Research shows LL-37 both stimulates and regulates immune responses: boosting pathogen clearance while preventing excessive inflammation — a nuanced immune modulation profile of research interest.
🩹 Wound Healing
LL-37 directly promotes keratinocyte migration, angiogenesis, and granulation tissue formation. Research in wound healing models shows accelerated re-epithelialization and tissue regeneration — an active area of therapeutic development for chronic wound research.
🔬 Anti-Tumor Research
LL-37 shows selective cytotoxicity against cancer cell lines including breast, colon, and lung cancer, while sparing normal cells in several research models — an active area of antimicrobial peptide-based cancer research.
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FOR RESEARCH USE ONLY (RUO). Not approved for human or veterinary use. Intended for in vitro and laboratory research only.
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