NAD+ — Nicotinamide Adenine Dinucleotide | Cellular Energy & Longevity Research
NAD+ (Nicotinamide Adenine Dinucleotide) is perhaps the most fundamental coenzyme in cellular biochemistry — serving as an electron carrier in mitochondrial energy production, a substrate for sirtuin deacetylases, PARPs, and CD38, and a master regulator of metabolic homeostasis. NAD+ levels decline by up to 50% between age 40 and 60, making NAD+ replenishment a central focus of anti-aging and longevity research.
Available Formats
- 100mg
- 500mg
- 1000mg
Reconstitution: Reconstitute with Bacteriostatic Water (BAC Water) for multi-use stability, or Sterile Water for single-use protocols. Store lyophilized vials at 2–8°C.
Key Research Areas
⚡ Mitochondrial Energy & ATP Production
NAD+ is the essential electron acceptor in the TCA cycle and oxidative phosphorylation. Research in aged animal models shows NAD+ restoration improves mitochondrial function, increases ATP production, and reverses mitochondrial fragmentation — producing measurable improvements in energy metabolism.
🧬 Sirtuin Activation & Epigenetic Research
Sirtuins (SIRT1-7) are NAD+-dependent deacetylases that regulate histone modification, gene expression, DNA repair, and metabolic adaptation. Research demonstrates sirtuin activation via NAD+ restoration extends lifespan in C. elegans, yeast, and mouse models — a central pillar of longevity research.
🔧 DNA Repair (PARP Activation)
PARPs (poly-ADP-ribose polymerases) consume NAD+ for DNA repair processes. Maintaining NAD+ availability supports genomic stability, reduces DNA damage accumulation, and may reduce cancer risk markers in aging research models.
🧠 Neuroprotection & Cognitive Research
NAD+ supports neuronal energy demands and axon integrity. Research in neurodegeneration models shows NAD+ supplementation protects against axonal degeneration, reduces amyloid beta toxicity, and improves cognitive function in aging models.
❤️ Cardiovascular & Metabolic Research
Studies show NAD+ restoration improves insulin sensitivity, lipid metabolism, and cardiac muscle function in metabolic disease models — positioning it as a broad metabolic research tool.
Why Choose EhBuddy?
- ✅ Verified Purity — Third-party tested for identity and potency
- ✅ Fast Canadian Shipping — Discreet packaging, shipped from Canada
- ✅ Research-Grade Quality — Strict manufacturing quality standards
- ✅ Multiple Vial Sizes — 100mg, 500mg, and 1000mg for scaled research protocols
FOR RESEARCH USE ONLY (RUO). Not approved for human or veterinary use. Intended for in vitro and laboratory research only. EhBuddy Peptides assumes no liability for misuse.
Catherine V. –
NAD+ is noticeably better than oral supplements I was using. EhBuddy’s shipping is fast and the product is exactly as described. Very happy with the entire experience.