PT-141 (Bremelanotide) — Central Sexual Function Research Peptide
PT-141, known generically as Bremelanotide, is a synthetic cyclic heptapeptide and melanocortin receptor agonist derived from Melanotan-2. Unlike erectile dysfunction compounds that work through vascular mechanisms, PT-141 activates MC4R receptors in the hypothalamus — directly engaging the CNS component of sexual arousal. It is the only FDA-approved peptide for HSDD (Hypoactive Sexual Desire Disorder) in females, providing an extraordinary research evidence base.
Available Formats
- 10mg
Reconstitution: Add 0.6% Acetic Acid first to dissolve the powder, then dilute with Bacteriostatic Water (BAC Water) or Sterile Water for your working solution. Store lyophilized vials at 2–8°C.
Key Research Areas
🔥 Central Sexual Arousal Mechanisms
PT-141 acts centrally rather than peripherally — bypassing the vascular mechanisms of PDE5 inhibitors to directly activate hypothalamic dopaminergic circuits. Research models demonstrate heightened sexual motivation, spontaneous erections, and lubrication responses independent of peripheral blood flow.
👩 Female Sexual Dysfunction Research
PT-141 holds FDA approval as Vyleesi for HSDD in premenopausal women — the only research-backed peptide compound with regulatory approval for female sexual dysfunction. Studies show significant improvements in desire, arousal, and satisfying sexual events.
👨 Male Erectile Function
Phase 2 research in male subjects demonstrated significant improvement in erectile function scores, including in men who were non-responsive to PDE5 inhibitors — opening a unique research avenue for refractory ED models.
🧠 Melanocortin CNS Pathway Research
PT-141 provides a precise research tool for studying the role of central melanocortin pathways in sexual behaviour, dopamine reward circuits, and hypothalamic regulation of desire.
Why Choose EhBuddy?
- ✅ Verified Purity — Third-party tested for identity and potency
- ✅ Fast Canadian Shipping — Discreet packaging, shipped from Canada
- ✅ Research-Grade Quality — Strict quality-control manufacturing standards
FOR RESEARCH USE ONLY (RUO). Not approved for human or veterinary use. Intended for in vitro and laboratory research only. EhBuddy Peptides assumes no liability for misuse.
Brandon K. –
PT-141 from EhBuddy is excellent quality. Arrived in 2 days, completely discreet. Combined with the insulin pen also ordered here — will definitely be a repeat customer.