Kisspeptin research in Canada investigates the reproductive neuroendocrine and GnRH pulse-regulating properties of this hypothalamic neuropeptide. Kisspeptin is a 54-amino acid peptide (and its shorter C-terminal fragments kp-10, kp-13, kp-14) encoded by the KISS1 gene that signals through the GPR54/KISS1R receptor on GnRH neurons. Canadian reproductive endocrinology researchers study kisspeptin as the master gatekeeper of GnRH secretion and the hypothalamic-pituitary-gonadal (HPG) axis, controlling puberty onset and reproductive competence in animal models.
GnRH Pulse Regulation Research
Kisspeptin neurons in the arcuate nucleus (KNDy neurons, which co-express kisspeptin, neurokinin B, and dynorphin) regulate the pulsatile release of GnRH from the median eminence. Kisspeptin binding to KISS1R on GnRH neurons is the most potent known stimulator of GnRH secretion. Canadian neuroendocrinology researchers use kisspeptin to study how GnRH pulse frequency and amplitude are regulated and how environmental and metabolic signals (energy balance, stress) are transduced into reproductive axis output through kisspeptin neurons.
Puberty and Fertility Research
Mutations in KISS1 or KISS1R cause hypogonadotropic hypogonadism and absent puberty in animal models and humans. Canadian reproductive biology researchers use kisspeptin to study the neuroendocrine mechanisms of puberty onset, including how kisspeptin neuron activation triggers the pubertal GnRH surge.
Sourcing Kisspeptin in Canada
Research-grade kisspeptin is available from EhBuddy Peptides in Canada. Lab-tested for purity. For laboratory research use only.
Kisspeptin is the master regulator of reproductive neuroendocrinology and one of the most important research peptides for Canadian HPG axis and puberty biology researchers.
