VIP research in Canada investigates the neuroprotective, anti-inflammatory, and circadian regulatory properties of vasoactive intestinal peptide. VIP is a 28-amino acid neuropeptide that signals through VPAC1 and VPAC2 receptors (G protein-coupled receptors) and is widely distributed in the nervous system, immune cells, and gut. Canadian neuroscience and immunology researchers study VIP for its roles in circadian rhythm regulation in the SCN, anti-inflammatory cytokine modulation, and neuroprotection in models of neurodegeneration.
Circadian Rhythm Research
VIP is a primary neurotransmitter in the suprachiasmatic nucleus (SCN), the brain’s master circadian clock. VIP-expressing neurons in the SCN synchronize circadian oscillations across the network through VPAC2 receptor signalling. Canadian chronobiology researchers study VIP’s role in coupling individual clock neurons into a coherent circadian signal and how disruption of VIP signalling affects circadian period and amplitude in animal models.
Anti-Inflammatory Research
VIP has potent anti-inflammatory properties mediated through VPAC receptors on immune cells. It suppresses TNF-alpha, IL-6, and IL-12 while promoting IL-10 production in macrophages and dendritic cells. Canadian immunology researchers study VIP as a neuropeptide-immune interface modulator in models of inflammatory disease and autoimmunity.
Sourcing VIP in Canada
Research-grade VIP (Vasoactive Intestinal Peptide) is available in Canada from EhBuddy Peptides. Lab-tested for purity. For laboratory research use only.
VIP is a multifunctional research neuropeptide in Canada, bridging chronobiology, neuroimmunology, and neuroprotection research in a single pharmacological tool.
